Clinical Success in Outpatient Treatment of Complicated Urinary Tract Infections with Ertapenem
November 14, 2013
SAN FRANCISCO, CA (October 4, 2013) – A retrospective database review was conducted of patients aged 18 and older receiving ertapenem therapy for UTI between July 1, 2010, and December 31, 2013. Seventy-five patients with a UTI diagnosis and available culture data were randomly selected from four participating Infectious Disease Physician Office Infusion Centers (POICs). Females accounted for 72%, 59% of patients had recurrent UTIs. Ertapenem was initiated in 55 % of patients in the POIC. E.coli was the predominant organism (75%). Overall ESBL and MDR rates in the outpatient setting were high. ESBL-producing organisms accounted for 82% and MDR was seen in 85% of organisms. Clinical success was achieved in 95% of patients (76% cured and 16% improved). Overall, adverse events occurred in 22 patients, almost all with mild to moderate reactions. The research suggests that treatment of complicated UTIs with ertapenem therapy achieved clinical success and was well tolerated. With a high success rate in drug-resistant pathogens, ertapenem appears to be safe and effective in the treatment of complicated UTIs in the POIC. To learn more, click here.
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Lucinda J. Van Anglen, PharmD